Just like any other drug, CBD is a chemical compound that has certain effects on different pathways in the body. Therefore, it is very important to understand whether these effects may be counterproductive or dangerous when consumed along with other drugs. Let’s take a look at some common medications that are known to interact with CBD oil.

Cytochrome P450 Enzymes’ Interactions with CBD Oil

Cytochrome P450 is a class of liver enzymes that are primarily in charge of the metabolic breakdown of numerous prescribed medications. In certain doses, CBD oil is known to temporarily deactivate Cytochrome P450 enzymes, leading to the prolonged activity as well as delayed metabolization of prescription medications.

Other CBD Oil Interactions with Prescription Drugs

Following are some other CBD oil interactions with common medications that are digested by Cytochrome P450 enzymes:

Medications for Peptic Ulcers and Gastrointestinal Reflux

Omeprazole such as the drugs Losec and Prilosec can be affected by the frequent use of CBD. These drugs are specifically targeted by the CYP enzyme CYP2D6. If a high dose of CBD is consumed before administration, the enzyme can be effectively blocked.

Blood Thinners

Heparin and warfarin are common blood thinner medications. These and many other similar medications are subject to increased effect and prolonged activity when taken along with cannabis.

Antipsychotic Medications for Autism, Bipolar, Schizophrenia, etc.

Risperidone is a commonly used antipsychotic medication that is mostly prescribed to cure mild cases of autism spectrum disorder (ASD), bipolar disorder, and schizophrenia. Like omeprazole, this drug is also targeted for metabolic breakdown by CYP enzymes. So, continuous, high doses of CBD can result in its prolonged activation.

Blood Pressure Medications

While CBD itself is not specifically known to increase blood pressure, its use with THC has been known to reduce arterial blood flow as well as initiate cardiac stress responses. Patients of high blood pressure need to be aware of the possibility that the use of cannabis may increase the overall effect of their medication, causing serious complications.

Seizure and Epilepsy Medications

While CBD for seizures and epilepsy is generally considered an effective and incredibly safe treatment option, a study showed that frequent use of cannabis can increase Clobazam levels in children.

What About CBD and Alcohol?

In terms of fatal or harmful side effects, combining alcohol with cannabis is normally regarded as being safe. But, it is by no means recommended because excessive use of alcohol is dangerous and not advised.


All in all, it can be concluded that CBD is generally regarded as therapeutic and incredibly safe medication, with virtually no risk for addiction/withdrawal or side effects. That being said, much more research is required to completely understand the interactions of CBD with other medications.

This article lists just a few common drugs that may interact with CBD. It is by no means a comprehensive guide on which drugs are safe to use with cannabis and which are not. It is recommended that you speak with a clinical professional or physician before making any changes to your medications.